・感染症や発がん機構などの生体反応について

・感染症における病態解析と抗原検査と抗体検査の検査系の開発と調査・研究

・各種検出系の開発・研究

Where there’s a will, there’s a way.（意思あるところに道は開ける)

Enjoy Life (人生を楽しむ)

免疫学、感染症学、腫瘍生物学、臨床検査医学、幹細胞医学

学士（保健学：東京医科歯科大学）

博士（生命科学：鳥取大学）

鳥取大学大学院医学系研究科博士後期課程

公益財団法人 島根県環境保健公社 臨床検査技師

ノースウェスタン大学 Microbiology-Immunology博士研究員

東京大学医科学研究所 感染症国際医療研究センター 研究員

独立行政法人国立国際医療研究センター免疫制御研究部 研究員

独立行政法人国立成育医療研究センター 生体防御系内科部感染症科 研究員

東京医科歯科大学難治疾患研究所 幹細胞医学分野 プロジェクト助教

東武医学技術専門学校 講師

【原著論文】

Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, and Nishimura EK. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science. 351: 575-589.2016.

Fukuda M, and Kawaguchi Y. Role of the Immunoreceptor Tyrosine based Activation Motif (ITAM) of Latent Membrane Protein 2A (LMP2A) in Epstein-Barr Virus LMP2A-induced Cell Transformation. Journal of Virology 88: 5189-5194. 2014.

Fukuda M, and Longnecker R. Epstein-Barr Virus (EBV) Latent Membrane Protein 2A Mediates Transformation through Constitutive Activation of the Ras/PI3- K/Akt Pathway. Journal of Virology 79: 9299-9306. 2007.

Fukuda M, Kurosaki H, and Sairenji, T. Loss of Functional Transforming Growth Factor-β (TGF-β) Type II Receptor results in insensitivity to TGF-β1 in Epstein Barr Virus-positive Burkitt’s Lymphoma Cell Line Akata. Journal of Medical Virology. 70: 244-252. 2006.

Fukuda M, and Longnecker R. Epstein-Barr Virus (EBV) Latent Membrane Protein 2A regulates B cell receptor-induced Apoptosis and EBV reactivation through tyrosine phosphorylation. Journal of Virology.79.8655-8660.2005.

Luo B, Murakami M, Fukuda M, Fujioka A, Yanagihara K, Sairenji T.  Characterization of Epstein-Barr virus infection in a human signet ring cell gastric carcinoma cell line, HSC-39. Microbes and Infection 6: 429-439. 2004.

Fukuda M, and Longnecker R. Latent membrane protein 2A inhibits. Transforming growth factor-β1-induced apoptosis through the phosphatidylinositol 3-Kinase/Akt pathway. Journal of Virology. 78: 1697-1705. 2004.

Jiang R, Kanamori M, Satoh Y, Fukuda M, Ikuta K, Murakami M, and Sairenji T. Contrasting effects of hydroxyurea on cell growth and reduction in Epstein-Barr virus genomes in EBV-infected epithelioid cell lines vs Burkitt’s lymphoma cell lines. Journal of Medical Virology. 70: 244-252. 2003.

Fukuda M, Kurosaki W, Yanagihara K, Kuratsune H, and Sairenji T. A mechanism in Epstein-Barr virus oncogenesis : Inhibition of transforming growth factor-beta1-mediated induction of MAPK/p21 by LMP1. Virology. 302: 310-320. 2002.

Fukuda M, Ikuta K, Yanagihara K, Tajima M, Kuratsune H, Kurata T, and Sairenji T. Effect of transforming growth factor-beta1 on the cell growth and Epstein-Barr virus reactivation in EBV-infected epithelial cell lines. Virology. 288:109-118. 2001.

Fukuda M, Satoh TA, Takanashi M, Hirai K, Ohnishi E, and Sairenji T. Inhibition of cell growth and Epstein-Barr virus reactivation by CD40 stimulation in Epstein-Barr virus-transformed B cells. Viral Immunology. 13: 215-229. 2000. 他 

【著書】

Ikeda M, Fukuda M, Longnecker R. 2005. Function of Latent Membrane Protein 2A, p. 533-552. In E. S. Robertson (ed.), Epstein-Barr Virus. Caister Academic, Press, Norfolk, England.

【研究助成金】

2008〜2010年度　科学研究助成事業基盤研究(C) 研究代表者

2008〜2010年度　科学研究助成事業基盤研究(B) 研究分担者

【受賞】

2003年：Gramm Travel Fellowship Award from the Robert H. Lurie Comprehensive Cancer Center of Northwestern University

2004～2005年：Phillip Morris External Research Program Postdoctral Fellowship  

【所属学会】

日本臨床衛生検査技師会

東京都臨床検査技師会

日本ウイルス学会

日本免疫学会

【国際会議】

(招待講演)

Fukuda, M. A mechanism of Epstein-Barr Virus (EBV) latency, persistence and tumorigenesis by EBV-encoded Latent membrane protein 2A. BIT’s 10^th Annual World DNA and Genome Day-2019. 2019. Nanjing, China.

Fukuda, M. The immunoreceptor tyrosine-based activation motif of Epstein-Barr Virus-encoded LMP2A plays a role in LMP2A-induced cell transformation. BIT’s 9^th World Gene Convention-2018. 2018. Venue: Singapore. 他

(一般演題)

Fukuda M, Longnecker R and Kawaguchi Y. The Immunoreceptor Tyrosine-based Activation Motif of EBV LMP2A Plays a Role in LMP2A-induced Transformation. 13^th International Symposium EBV and Associated Diseases. 2008. Guangzhou, China.

Fukuda M, and Longnecker R. Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the RAS/PI3-K/AKT Pathway. 32th Annual International Herpesvirus Workshop. 2007. Asheville USA.

Fukuda M, and Longnecker R. EBV latent membrane protein 2A inhibits B cell receptor (BCR)-induced Apoptosis and EBV reactivation through the inhibition of BCR-induced tyrosine phosphorylation. 29^th Annual International Herpesvirus Workshop. 2004. Nevada USA.

Fukuda M, and R. Longnecker. EBV latent membrane protein 2A inhibits transforming growth factor-β1-mediated growth inhibition and apoptosis. 28th Annual International Herpesvirus Workshop.2003. Wisconsin. USA.

Fukuda M, Yanagihara K, Tajima M, Sairenji T. Effect of transforming growth factor-β1 on the cell growth and Epstein-Barr virus (EBV) reactivation in EBV-infected epithelial cell lines. 21st International symposium of the Sapporo cancer seminar:Epstein-Barr virus and human cancer. 2001. Sapporo Japan. 他

東北医科薬科大学医学部微生物学教室